Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer

Figure 6

Anlotinib combined with 5-FU affected cell proliferation and angiogenesis in vivo. 24 male BALB/c-nu mice were randomly divided into four groups treated with oral saline, 1.5 mg/kg anlotinib, 100 mg/kg 5-FU, or both of anlotinib and 5-FU. (a) Tumor volume in mice after 21-day treatment. (b) The protein expression for each group. (c) The relative protein expression levels of each group. The results are from three independent experiments. and compared with anlotinib.

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(b)

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