Research Article
TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2
Figure 3
The COL1A2 promoter is significantly regulated by an enhancer-like signature. (a) COL1A2 promoter modification level searched by UCSC browser. (b, c) ChIP-seq data of H3K27ac in GC and normal gastric tissues were downloaded from the GEO database and analyzed for enrichment in the COL1A2 promoter. (d) ChIP-qPCR analysis of COL1A2 promoter histone H3K27ac modification levels in AGS and MKN-45 cells. Data indicate of three biological replicates. Two-way ANOVA and Tukey’s multiple comparison test; (vs. IgG).
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