Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer

Table 2

Top scored three Molecular Complex Detection (MCODE) clusters and significantly enriched pathways. FDR: false discovery rate.

MCODE	Genes	Interactions	Gene symbols	Enriched pathways ()
1	61	1791	RPS27, RPS23, RPS14, RPL10L, RPL10, EIF3D, EIF3B, RPL24, RPS21, RPSA, NHP2L1, FBL, RPL7A, RPS16, RPS10, RPL19, RPL13, RPL4, RPS7, RPS3, RPL38, RPS26, RPL6, RPS4X, RPS3A, RPL18, RPL29, RPL14, RPS5, RPL35, RPS25, RPL3, RPL10A, RPS24, RPS15A, RPL12, RPL26, RPS19, RPL32, RPL18A, RPS11, RPL15, RPL36, RPL22, RPLP0, RPS2, RPL21, RPL13A, EIF4B, NSA2, EIF3K, EIF3F, EIF4A1, GNB2L1, EIF3A, EEF1B2, EIF3G, EEF1A1, EEF1G, EEF2, RPS6	hsa03010:ribosome
2	14	45	SPARC, GABBR1, TIMP1, CNR2, GNG7, CCL5, TGFB1, GNG11, GNG8, F13A1, P2RY12, CLU, ITIH4, ACTN1	NA
3	28	86	HLA-DPA1, HLA-DPB1, LSM7, HIST1H2AM, DNM3, CTTN, HIST1H2AI, HIST1H2BF, HLA-DRB1, HLA-DRB5, CIITA, H2AFJ, HIST1H2BK, HIST1H2AA, HIST1H2BB, HIST1H2AE, HIST2H2BE, RAN, HLA-DMA, DAB2, LDLRAP1, HLA-DQA1, SNRPD1, REPS1, HLA-DQB1, STON2, PPIH, RBMX	hsa05322:systemic lupus erythematosus; hsa05310:asthma; hsa05332:graft-versus-host disease; hsa05330:allograft rejection; hsa04940:type I diabetes mellitus; hsa04612:antigen processing and presentation; hsa04672:intestinal immune network for IgA production; hsa05320:autoimmune thyroid disease; hsa05150:Staphylococcus aureus infection; hsa05416:viral myocarditis; hsa05321:inflammatory bowel disease (IBD); hsa05145:toxoplasmosis; hsa05034:alcoholism; hsa05140:leishmaniasis; hsa05323:rheumatoid arthritis; hsa05164:influenza A; hsa05152:tuberculosis; hsa04514:cell adhesion molecules (CAMs); hsa04145:phagosome; hsa05166:HTLV-I infection; hsa05168:herpes simplex infection