Analytical Cellular Pathology

Molecular Regulation of Cancer Cell Migration, Invasion, and Metastasis


Status
Published

1Hashemite University, Zarqa, Jordan

2Antwerp University Hospital, Edegem, Belgium

3University of Jordan, Amman, Jordan

4Virginia Commonwealth University, Richmond, USA


Molecular Regulation of Cancer Cell Migration, Invasion, and Metastasis

Description

Cancer metastasis represents an advanced stage of malignancy and is the leading cause of cancer-related deaths. Metastasis is a multistep process that includes migration and invasion of cancer cells, hallmarks of malignancy. These processes require the involvement of a wide array of cellular mechanisms led by cytoskeleton dynamics as well as molecular alterations such as expression of adhesion and proteolytic enzymes. Cell migration in itself is a highly integrated process that includes development of cytoplasmic protrusions, attachment, and traction. Additional secondary changes associated with cell migration and invasion include production of reactive oxygen species (ROS), development of chemoresistant cancer stem cells, introduction of mutations in DNA damage repair genes, and contribution of microRNAs (miRNAs). Cell release of exosomes and their participation in modulating cell behavior are a new and exciting observation.

We invite researchers to contribute original research papers as well as review articles that address cellular and molecular factors that impact migratory and invasive cell behavior.

Potential topics include but are not limited to the following:

  • The role of actin-binding proteins in cancer migration and invasion
  • The role of miRNAs in cancer invasion and metastasis
  • The effect of oxidative stress on cancer cell metastasis
  • DNA damage repair during cancer cell metastasis
  • The role of exosomes in cancer migration and invasion
  • Epithelial-mesenchymal transition during cancer cell migration and invasion
  • Recent advances in cancer stem cells and metastasis

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 1356508
  • - Editorial

Molecular Regulation of Cancer Cell Migration, Invasion, and Metastasis

Lubna Tahtamouni | Mamoun Ahram | ... | Christian Rolfo
  • Special Issue
  • - Volume 2019
  • - Article ID 9192516
  • - Research Article

The Laminin-α1 Chain-Derived Peptide, AG73, Binds to Syndecans on MDA-231 Breast Cancer Cells and Alters Filopodium Formation

Madhavi Puchalapalli | Liang Mu | ... | Jennifer E. Koblinski
  • Special Issue
  • - Volume 2019
  • - Article ID 7145198
  • - Research Article

PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway

Xiangyu Kong | Ganghao Ai | ... | Yongxing Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 9432375
  • - Research Article

Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases

Ivana Miše | Majda Vučić
  • Special Issue
  • - Volume 2018
  • - Article ID 9275685
  • - Research Article

LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activating the PI3K/AKT Pathway

Ran Gao | Rui Zhang | ... | Weining Tang
  • Special Issue
  • - Volume 2018
  • - Article ID 5917470
  • - Research Article

Metformin Treatment Inhibits Motility and Invasion of Glioblastoma Cancer Cells

Marwa Al Hassan | Isabelle Fakhoury | ... | Mirvat El-Sibai
  • Special Issue
  • - Volume 2018
  • - Article ID 8389595
  • - Review Article

Heparan Sulfate Proteoglycans in Human Colorectal Cancer

Carolina Meloni Vicente | Daiana Aparecida da Silva | ... | Leny Toma
Analytical Cellular Pathology
 Journal metrics
Acceptance rate25%
Submission to final decision83 days
Acceptance to publication41 days
CiteScore2.300
Impact Factor2.052
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