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Autoimmune Diseases
Volume 2010 (2010), Article ID 285974, 5 pages
http://dx.doi.org/10.4061/2010/285974
Research Article

Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60G Allele

Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary

Received 4 June 2009; Accepted 2 August 2009

Academic Editor: Rizgar Mageed

Copyright © 2010 Bernadett Farago et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene's variants with rheumatoid arthritis (RA). After genotyping 428 patients and 230 matched controls, the prevalence of the G allele was more frequent in RF- and/or anti-CCP-seropositive RApatients, compared to the healthy controls ( ). Regression analysis revealed that the G allele is a possible predisposing factor for RA in these subgroups. No accumulation of the G allele was found among patients, and this variant was not found to correlate with RA. Assaying the possible genotype variations, the G- G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA ( , for the whole RA-population). Although the G allele did not mean a predisposition to RA alone, in combination with G it, also conferred risk, suggesting that the variant is associated with the risk of RA only in certain haplotypes.