Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60∗G Allele
Table 1
The distribution and frequencies of the CTLA4 CT60 and +49A/G genotypes and alleles, and the +49*G-CT60*G haplotype stratified by RF- and anti-CCP-seropositivity in patients versus controls.
RA patients
Control
RF
anti-CCP
RF + anti-CCP
Total
Positive
Negative
Positive
Negative
Positive-positive
Negative-negative
Total
()
()
()
()
()
()
()
()
CT60
AA (%)
84 (19.6)*
62 (19.1)*
22 (21.2)
59 (19.0)*
25 (21.2)
54 (18.9)*
17 (21.3)
64 (24.0)
GA (%)
199 (46.5)
143 (44.1)
56 (53.8)
131 (42.3)
68 (57.6)
122 (42.7)
47 (58.8)
109 (48.8)
GA+GG (%)
344 (80.4)
262 (80.9)
82 (78.8)
251 (81.0)
93 (78.8)
232 (81.1)
63 (78.8)
166 (78.4)
GG (%)
145 (33.9)*
119 (36.7)*
26 (25.0)
120 (38.7)*
25 (21.2)
110 (38.5)*
16 (20.0)
57 (27.1)
G (%)
489 (57.1)*
381 (58.8)*
108 (51.9)
371 (59.8)*
118 (50.0)
342 (59.8)*
79 (49.4)
223 (48.5)
+49A/G
AA (%)
160 (37.4)
122 (37.7)
38 (36.5)
112 (36.1)
48 (40.7)
104 (36.4)
30 (37.5)
98 (42.6)
GA (%)
201 (47.0)
151 (46.6)
50 (48.1)
147 (47.4)
54 (45.8)
135 (47.2)
38 (47.5)
97 (42.2)
GA+GG (%)
268 (62.6)
202 (62.3)
66 (63.5)
198 (63.9)
70 (59.3)
182 (63.6)
50 (62.5)
132 (57.4)
GG (%)
67 (15.7)
51 (15.7)
16 (15.4)
51 (16.5)
16 (13.6)
47 (16.4)
12 (15.0)
35 (15.2)
G (%)
335 (39.1)
253 (39.0)
82 (39.4)
249 (40.2)
86 (36.4)
229 (40.0)
62 (38.8)
167 (36.3)
+49*G-CT60*G
182 (21.3)*
147 (22.7)*
35 (16.8)
147 (23.7)*
35 (14.8)
134 (23.4)*
22 (13.8)
62 (13.5)
*
in the prevalence of the AA and GG genotypes, the G allele, or the +49*G-CT60*G haplotype versus controls.
