Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE

Table 3

Anti-DNA autoantibodies properties.

dsDNA antibodies	ssDNA antibodies
Ig class: IgG and IgM	Ig class: IgG and IgM
IgG subclass: IgG3	IgG subclass: IgG1 and IgG3
PATHOGENICITY: based upon binding criteria	PATHOGENICITY: based upon binding criteria
(i) Some forms of lupus nephritis	(i) Non-pathogenic?
(ii) CNS involvement	(ii) Pathogenic and nephrogenic in human and murine models
(iii) Correlates with disease activity	(iii) Predictors of lupus flares and anti-dsDNA increase in humans
Abzymes and DNA-hydrolytic activity	ABZYMES and DNA-HYDROLYTIC ACTIVITY
Human and mouse mono- and polyclonal	Mouse monoclonal. Human?
CYTOTOXIC ACTIVITY	CYTOTOXIC ACTIVITY
Human polyclonal	Undetermined⋯for now