5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice
Figure 3
Effect of 5-AED in suspension (a) and soluble formulation (b) on Experimental Autoimmune Encephalomyelitis. Disease was induced in female SJL/J mice ( = 10) by subcutaneous immunization with . Mice began receiving daily s.c. injections with (40, 4 or 0.4 mg/kg) 5-AED (square, open circle, open diamond, resp.) or vehicle (triangle) 8–11 days later (onset). Disease scores were evaluated daily as indicated in Methods. Values in the figure are expressed as mean ± one standard deviation (error bars included for vehicle and 40 mg/kg groups). Statistical analysis of cumulative clinical scores was performed by ANOVA analysis for unpaired data. A value <.05 was considered to be statistically significant. For statistical analysis, the mice that succumbed to EAE were assigned 5 only for the day of death and then were deleted from the experimental group.
