The Effects of Omega-3 Fatty Acids on Matrix Metalloproteinase-9 Production and Cell Migration in Human Immune Cells: Implications for Multiple Sclerosis
Figure 2
Mean MMP-9 activity from PBMC supernatants. PBMC from three different normal controls. MMP-9 activity from supernatants of ConA-stimulated PBMC is decreased following treatment with DHA and EPA when compared to an untreated ConA-stimulated PBMC control (100% MMP-9 activity). OA served as an oil control and showed no significant decrease in MMP-9 levels at any concentration. PBMC were pretreated for 2 hr in the presence of 10, 25, and 50 μg/mL of one of the following, DHA, EPA, or OA. Cells were then stimulated with ConA and supernatants were collected to determine MMP-9 activity by gelatin substrate zymography. Error bars represent SE. *Significant decrease compared to control ().
