Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is Fc𝛾RIIB Dependent

Table 1

Effect of transgenic expression of human CRP on the outcome of EAE in mice lacking various Fcγ receptorsa.

Strain	No. mice	Clinical measure of disease symptoms
		Day of onset		Severity		CDI^b
		mean±sem		mean±sem
Wildtype	26	16.5±0.6		3.9±0.1		46.55
CRPtg	13	20.3±0.8	𝑃<.001^c,d	4.1±0.2	ns^c	32.8
FcγRI^-/-	9	16.3±0.9	ns^c	3.3±0.2	ns^c	38.78
FcγRI^-/-/CRPtg	13	21.6±1.3	𝑃<.001^d	2.7±0.1	𝑃<.01^d	18.21
FcγRIIb^-/-	9	15.1±0.4	ns^c	4.2±0.2	ns^c	55.33
FcγRIIb^-/-/CRPtg	10	15.2±0.3	ns^d	4.1±0.3	ns^d	51.83
FcγRIII^-/-	16	15.6±0.5	ns^c	4.4±0.2	ns^c	50.58
FcγRIII^-/-/CRPtg	8	18.4±0.5	𝑃<.05^d	3.1±0.2	𝑃<.05^d	29.63

^aEAE was induced with MOG peptide as described in Section 2.
^bCumulative disease index (area under the curve: arbitrary units as described in Section 2).
^cResults of Neuman-Keuls multiple comparison test comparing indicated genotype to wildtype
^dResults of Neuman-Keuls multiple comparison test comparing indicated CRPtg genotype to its non-CRPtg littermates.