Review Article
A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis
| Manufacturer/test type | Test* | Cut point (U/mL) | Sensitivity (%) | Specificity (%) | References |
| Abbott Laboratories | Anti-CCP | 5 | 69.4 | 97.6 | [23] | AxSYM | 5 | 80.6 | 84.3 | [24] | | Anti-CCP2 | | | | | Axis-Shield Diagnostics | Anti-CCP | 7.2 | 52.8 | 100 | [25] | Anti-CCP2 | 4.5 | 82.4 | 82.8 | [26] | 4.6 | 83.3 | 93 | [27] | 5 | 53.7–67.5 | 90.4–99.3 | [28–31] | 5.6 | 88 | 81 | [32] | 25 | 71 | 65 | [10] | Eurodiagnostica | Anti-CCP | 20.7 | 52.8 | 100 | [25] | 53 | 47 | 94 | [33] | 65 | 43.8 | 98.4 | [34] | Anti-CCP2 | 5 | 66.7 | 97 | [29] | 25 | 66.7–76.5 | 92.2–97.3 | [29, 35–37] | 42 | 73.7 | 98.6 | [36] | Euroimmun | Anti-CCP | 5 | 39.2–65 | 95.2–99 | [38–41] | 14.8 | 81.6 | 87.5 | [42] | 25 | 56 | 96 | [43] | Anti-CCP2 | 5 | 66.7–72.5 | 96.4–97.7 | [29, 35] | 5.25 | 78.7 | 95.6 | [44] | Fuchun-Zhongnan Biotech | Anti-CCP2 | 25 | 61.8 | 96.3 | [45] | Genesis | Anti-CCP2 | 6.25 | 69.6 | 93.9 | [35] | Immunoscan | Anti-CCP2 | 25 | 54–64.4 | 96–97.1 | [46, 47] | In-house ELISA test | Anti-CCP1 | 92 | 42 | 97 | [47] | INOVA Diagnostics | Anti-CCP | 6.4 | 58.5 | 100 | [25] | Anti-CCP2 | 20 | 60.2–78.6 | 70.3–98.8 | [22, 24, 29, 35, 48–52] | 25 | 82 | 96 | [53] | 30 | 70 | 91.5 | [54] | Anti-CCP3 | 20 | 61.3–82.9 | 93–97.6 | [24, 29, 49, 51] | MBL Co. | Anti-CCP | 3.8 | 72.8 | 92 | [55] | Phadia GmbH | Anti-CCP2 | 7 | 77.5 | 95.9 | [35] | 10 | 70.1 | 98.7 | [56] | Pharmacia Diagnostica | Anti-CCP2 | 7 | 80.3 | 97 | [22] | Roche Diagnostics | Anti-CCP2 | 9 | 69 | 93 | [57] | 13.6 | 92.2 | 86.2 | [58] | 17 | 90.6 | 86.8 | [58] |
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generation of anti-CCP test indicated is as reported in the methods section of the articles referenced.
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