The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis

Figure 2

Histopathologic features representative of the EAU scores. Mice control shows ocular lesions characterized by cells infiltrating the vitreous and vasculitis (a) and (b); in mice injected with K⁴⁰⁹A, it is possible to observe inflammatory cells in the vitreous and retinal folds (c) and (d); mice injected with Leader pep show cells in the vitreous and retinal folds (e) and (f); mice injected with K⁴⁰⁹A pep exhibit a normal retinal architecture corresponding to nonimmunized naïve mice (g) and (h). Representative photographs (hematoxylin-eosin staining). Original magnifications: 100× (left); 400× (right).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)