Autoimmune Diseases / 2012 / Article / Tab 1

Review Article

Genetic Factors of Autoimmune Thyroid Diseases in Japanese

Table 1

PTPN22 haplotype structure and frequenciesa.

SNP IDHaplotype comparisonb
Haplotype12345AITDGDHTControlsAITD versus Controls valueGD versus Controls valueHT versus Controls value

1CTTGA0.590.590.590.600.690.750.69
2CCTGC0.200.200.200.170.240.290.28
3CCCAA0.130.130.130.120.540.660.47
4TCCGA0.0670.0660.0700.0600.630.720.61
5CCTGA0.0130.0170.00610.051<0.0001<0.00010.0004

aThe program, SNPAlyze ver. 7.0 Standard, was used to estimate common (frequencies > 0.01) haplotypes for the five SNPs genotyped.
bEach haplotype was compared with the other haplotypes combined.
SNP: single nucleotide polymorphism; AITD: autoimmune thyroid disease; GD: Graves’ disease; HT: Hashimoto’s thyroiditis.

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