A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts
Table 3
(a) Responses to human AChR. (b) Responses to T. californica AChR. (c) Responses to all other AChRs.
(a)
B cell epitopes
T-cell epitopes
Total
Host
Human
20
260
280
Mouse
25
62
87
Rat
29
5
34
Rabbit
13
0
13
Dog
1
0
1
Cat
1
0
1
99
327
416
(b)
B cell epitopes
T-cell epitopes
Total
Host
Mouse
62
42
104
Rat
75
28
103
Rabbit
43
0
43
Human
5
4
9
Dog
2
0
2
187
74
261
(c)
B cell epitopes
T-cell epitopes
Total
Host
Mouse
4
5
9
Rat
24
1
25
Human
0
11
11
Rabbit
20
0
20
48
17
75
These data were derived using the Source Antigen Molecule Finder to specify AChR, selecting B cell and T-cell responses only (MHC binding and MHC ligand elution assays were excluded). For this analysis Host Organism was not specified. Positive T-cell and B cell Response data were downloaded separately into Excel format and further analyzed to determine the number of B and T-cell epitopes per host species reacting to either AChR. Listed in the table are the total numbers of epitopes (distinct molecular structure).
