A Comparison of Epitope Repertoires Associated with Myasthenia Gravis in Humans and Nonhuman Hosts

Table 4

Disease-associated data.

Disease	Epitopes	Negative peptides	Total tested	References
Myasthenia gravis	301	104	405	49
T-cell assays	434	273	707
B cell assays	49	19	68
Experimental autoimmune, Myasthenia gravis, EAMG	78	10	88	39
T-cell assays	152	83	235
B cell assays	62	12	74

These data were derived by selecting “myasthenia gravis” as the disease. Host organism was not specified; therefore the data for MG will include dog and cat as hosts, in addition to human subjects. MHC binding and MHC Ligand elution assays were excluded. “Positive epitopes” refer to those peptides/structures found to be positive in at least one measurement. “References” refer to studies published in peer-review literature and contained in PubMed. Acquired MG includes human, cat and dogs as host. EAMG includes rabbits, rats and mice, including human transgenic mouse strains. Listed in the table are the total numbers of epitopes (distinct molecular structure) and then distinct assays captured within the database. By definition this number does not indicate the number of individual epitopes, as each epitope is defined experimentally by one or more assays.