Review Article

Local Cartilage Trauma as a Pathogenic Factor in Autoimmunity (One Hypothesis Based on Patients with Relapsing Polychondritis Triggered by Cartilage Trauma)

Figure 1

Local cartilage trauma initiates an inflammatory process with or without infection as coadjuvant as well as activation of the innate and adaptive immunity through induction of PAMPs, DAMPs, and cryptogenic antigens which are recognized by PRR (TLR, NLR) that results in the production of IL-1B and IL-18. These interleukins amplify T and B cell responses and might serve as a crucial link into adaptive immune responses. PRR, pattern recognition receptors; TLR, Toll-like receptors; NLR, NOD-like receptors; LTCD4, lymphocytes T CD4.