Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications

Table 3

Soluble heat shock proteins and their association with cardiovascular diseases.

Soluble heat shock protein subtype	Number of patients	Cardiovascular disease	Study finding	Reference
HSP70	24	Acute myocardial infarction	Soluble HSP70 is released into the circulation after an acute myocardial infarction	[28]
HSP60	684	Carotid atherosclerosis	Levels of soluble HSP60 are associated with early carotid atherosclerosis	[29]
HSP70	52 cases; 20 controls	Acute myocardial infarction	Levels of soluble HSP70 are associated with progression of heart failure after acute myocardial infarction	[30]
HSP60, HSP72	88 cases; 44 controls	Idiopathic left ventricular dysfunction	Levels of soluble HSP60 and HSP72 correlate with severity of cardiac and microvascular dysfunction in patients with idiopathic left ventricular dysfunction	[15]
HSP70	167	Congestive heart failure	Levels of soluble HSP70 are associated with severity of heart failure in patients with congestive heart failure	[31]
HSP60	1003 cases; 1003 controls	Coronary artery disease	Levels of soluble HSP60 correlate with the presence of coronary artery disease	[32]