Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis
Table 1
Associations between HLA class II and six ADs: SLE, RA, T1D, AIH, SS, and MS.
Association
Allele
AD
OR
Lower limit
Upper limit
valuea
Risk (for only one AD)
DQA1*03:01
T1D
2.65
1.23
5.72
0.013
DQA1*05:01
T1D
2.43
1.34
4.38
0.003
DQB1*02:01
T1D
2.97
2.05
4.30
<0.001
DQB1*03:02
T1D
4.45
3.29
6.02
<0.001
DRB1*03
T1D
2.69
1.41
5.15
0.003
DRB1*04
T1D
3.83
2.02
7.27
<0.001
DRB1*04:02
T1D
3.23
1.63
6.39
0.001
DQB1*06
MS
2.18
1.55
3.08
<0.001
DRB1*15:01
MS
2.59
1.68
4.02
<0.001
DRB1*15:03
MS
2.24
1.39
3.62
0.001
DRB1*01:01
RA
1.71
1.23
2.39
0.002
DRB1*04:04
RA
3.42
1.54
7.63
0.003
DRB1*13:01
AIH
4.84
2.83
8.26
<0.001
Risk (for more than one AD)
DRB1*04:01
T1D and RA
3.86
2.32
6.42
<0.001
DRB1*03:01
SLE, SS and T1D
3.56
1.42
11.54
0.009
DRB1*04:05
AIH, T1D and RA
4.64
2.14
10.05
<0.001
Protection (for only one AD)
DQB1*05
T1D
0.31
0.19
0.51
<0.001
DQB1*05:01
T1D
0.41
0.24
0.68
<0.001
DRB1*11
T1D
0.27
0.17
0.42
<0.001
DRB1*13
T1D
0.37
0.24
0.58
<0.001
DRB1*14
T1D
0.18
0.06
0.55
0.002
DQB1*03:01
AIH
0.33
0.19
0.56
<0.001
DRB1*13:02
AIH
0.16
0.05
0.45
0.001
DRB1*11:01
SLE
0.21
0.006
0.72
<0.001
Opposite associations
DQB1*06:02
MS risk
2.49
1.67
3.71
<0.001
T1D protection
0.17
0.09
0.29
<0.001
DQB1*06:03
AIH risk
4.48
1.28
15.73
<0.001
T1D protection
0.29
0.18
0.87
<0.001
DRB1*15
MS risk
2.28
1.69
3.07
<0.001
T1D protection
0.38
0.22
0.65
<0.001
aα = 0.05. Each OR and its CI show the effect size and precision for individual studies and for the combined effect calculated by the random model. AD: autoimmune disease; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; AIH: autoimmune hepatitis; T1D: type 1 diabetes; SS: Sjögren’s syndrome; MS: multiple sclerosis; OR: odds ratio.
