Review Article

Epigenetics and Autoimmune Diseases

Figure 1

Epigenetic-environmental interaction. Offspring of pregnant Agouti rodents fed with food rich in methyl donors had a different color of coat (brown, (b)) due to an increased DNA methylation status in the viable yellow allele ( allele), in comparison to offspring of pregnant rodents fed a normal diet (yellow or mottle, (a)). Intracisternal A Particle (IAP), Transcription Factor (TF), RNA Polymerase (RNA Pol), Methylated Cytosine (M).
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(a)
593720.fig.001b
(b)