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Autoimmune Diseases
Volume 2012, Article ID 645967, 11 pages
http://dx.doi.org/10.1155/2012/645967
Review Article

Neurological Disorders in Primary Sjögren's Syndrome

1EA Immunologie et Pathologie, Université de Bretagne Occidentale et Centre Hospitalier Universitaire de Brest, BP 824, F2969 Brest, France
2Laboratory of Immunology, Brest University Medical School, BP 824, 2969 Brest, France

Received 11 October 2011; Accepted 15 December 2011

Academic Editor: Jozélio Freire de Carvalho

Copyright © 2012 Gabriel J. Tobón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands. The histopathological hallmark is periductal lymphocytic infiltration of the exocrine glands, resulting in loss of their secretory function. Several systemic manifestations may be found in patients with Sjögren's syndrome including neurological disorders. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. This paper endeavors to review the main clinical neurological manifestations in Sjögren syndrome, the physiopathology, and their therapeutic response.