Table 2: Antibodies in neurological manifestations of primary Sjögren’s syndrome.

AntibodyClinical associationReference

Anti-SSA and anti-SSBMost of studies show lower prevalence of anti-SSA and anti-SSB antibodies in pSS with neurological involvement. In one series, patients with nonataxic sensory neuropathy had lower prevalence of anti-SSA (40% versus 72%) and anti-SSB (15% versus 41%).Sene et al. [85]

Anti-SSAThis paper showed that anti-Ro antibodies were positive in 48% of patients with CNS compared to only 24% of all patients with pSS. However, the anti-SSA antibodies were detected by double immunodiffusion and not by ELISA.Alexander et al. [18]

Anti-alpha fodrin (IgA and IgG)These antibodies are common patients in pSS. However, there are not differences between patients with or without clinical neurological involvement.De Seze et al. [88]

Anti-GM1 (IgM and IgG)No differences between pSS patients with or without neurological involvement.Giordano et al. [81]

Antineuronal antibodiesIn a large series of patients with neurological disorders ( ), these antibodies were detected in patients with pSS and neurological involvement, although the specificity has to be defined. Antiganglion neuron antibodies have been also reported.Murata et al. [25], Vianello et al. [82]

Anti-GW182Detected in patients with mixed motor and/or sensory neuropathy without pSS and also in neurological involvement in pSS patients.Eystathioy et al. [83]

GM1: ganglioside; GW182: protein located in cytoplasmic structures called GW bodies; CNS: central nervous system; pSS: primary Sjögren syndrome.