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Autoimmune Diseases
Volume 2012 (2012), Article ID 683829, 7 pages
http://dx.doi.org/10.1155/2012/683829
Research Article

Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain

1State Research Center for Applied Microbiology and Biotechnology, Serpuhov District Obolensk 142279, Russia
2Institute of Immunological Engineering, Lyubuchany 142380, Russia
3Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, Moscow 117997, Russia

Received 4 June 2012; Accepted 27 September 2012

Academic Editor: Hiroyuki Nishimura

Copyright © 2012 A. V. Kozyr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite this Article

A. V. Kozyr, A. V. Kolesnikov, A. E. Khlyntseva, et al., “Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain,” Autoimmune Diseases, vol. 2012, Article ID 683829, 7 pages, 2012. doi:10.1155/2012/683829