The Autoimmune Tautology: An In Silico Approach

Table 5

Relevance on autoimmunity GWAS of the genes with a contribution higher than 1% to two or more clusters of the studied autoimmune diseases.

Gene	Full name	Location	GWAS catalogue	Reference
HLA-DQB1	Major histocompatibility complex, class II, DQ beta 1	6p21.3	MS, PBC, RA, SSc, CD, UC, CrD	[31]
CD4	CD4 molecule	12pter-p12	—	—
CTLA4	Cytotoxic T-lymphocyte-associated protein 4	2q33	T1D, RA, MS, SLE, CD	[32, 33]
FASLG	Fas ligand (TNF superfamily, member 6)	1q23	CD, CrD	—
IL1B	Interleukin 1, beta	2q14	—	—
IL10	Interleukin 10	1q31-q32	T1D, SLE, UC, CrD	[34]

MS: multiple sclerosis, PBC: primary biliar cirrhosis, RA: rheumatoid arthitis, SSc: systemic sclerosis, CD: celiac disease, CrD: crohn disease, T1D: Type 1 diabetes, SLE: systemic lupus erithematosus, UC: ulcerative colitis, PSO: Psoriasis.