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Autoimmune Diseases
Volume 2012, Article ID 819634, 11 pages
http://dx.doi.org/10.1155/2012/819634
Research Article

Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort

1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
2Department of Medicine and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
3Department of Biology, Harding University, Searcy, AR 72143, USA
4Department of Biostatistics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
5Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
6Divison of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
7US Department of Veterans Affairs Medical Center, Oklahoma City, OK 73105, USA
8US Department of Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
9Division of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA

Received 3 May 2012; Accepted 13 June 2012

Academic Editor: Taku Yoshio

Copyright © 2012 Rufei Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Sherer, A. Gorstein, M. J. Fritzler, and Y. Shoenfeld, “Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients,” Seminars in Arthritis and Rheumatism, vol. 34, no. 2, pp. 501–537, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Agmon-Levin, M. Mosca, M. Petri, and Y. Shoenfeld, “Systemic lupus erythematosus one disease or many?” Autoimmunity Reviews, vol. 11, no. 8, pp. 593–595, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Mahler, K. Miyachi, C. Peebles, and M. J. Fritzler, “The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA),” Autoimmunity Reviews, vol. 11, no. 10, pp. 771–775, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. L. D. Heinlen, M. T. McClain, L. L. Ritterhouse et al., “60 kD Ro and nRNP A frequently initiate human lupus autoimmunity,” PLoS One, vol. 5, no. 3, p. e9599, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. L. D. Heinlen, M. T. McClain, J. Merrill et al., “Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms,” Arthritis and Rheumatism, vol. 56, no. 7, pp. 2344–2351, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. M. R. Arbuckle, M. T. McClain, M. V. Rubertone et al., “Development of autoantibodies before the clinical onset of systemic lupus erythematosus,” New England Journal of Medicine, vol. 349, no. 16, pp. 1526–1533, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. M. R. Arbuckle, J. A. James, G. J. Dennis et al., “Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus,” Lupus, vol. 12, no. 2, pp. 99–106, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. R. Arbuckle, J. A. James, K. F. Kohlhase, M. V. Rubertone, G. J. Dennis, and J. B. Harley, “Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus,” Scandinavian Journal of Immunology, vol. 54, no. 1-2, pp. 211–219, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. L. D. Heinlen, L. L. Ritterhouse, M. T. McClain et al., “Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides,” Journal of Molecular Medicine, vol. 88, no. 7, pp. 719–727, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. B. E. Gilliam, A. K. Ombrello, R. W. Burlingame, P. H. Pepmueller, and T. L. Moore, “Measurement of autoantibodies in pediatric-onset systemic lupus erythematosus and their relationship with disease-associated manifestations,” Seminars in Arthritis and Rheumatism, vol. 41, no. 6, pp. 840–848, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. J. B. Harley, A. L. Sestak, L. G. Willis, S. M. Fu, J. A. Hansen, and M. Reichlin, “A model for disease heterogeneity in systemic lupus erythematosus. Relationships between histocompatibility antigens, autoantibodies, and lymphopenia or renal disease,” Arthritis and Rheumatism, vol. 32, no. 7, pp. 826–836, 1989. View at Google Scholar · View at Scopus
  12. C. A. Hitchon and C. A. Peschken, “Sm antibodies increase risk of death in systemic lupus erythematosus,” Lupus, vol. 16, no. 3, pp. 186–194, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. L. M. Vilá, G. S. Alarcón, G. McGwin, H. M. Bastian, B. J. Fessler, and J. D. Reveille, “Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual,” Arthritis Care and Research, vol. 55, no. 5, pp. 799–806, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. E. J. Ter Borg, G. Horst, E. J. Hummel, P. C. Limburg, and C. G. M. Kallenberg, “Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study,” Arthritis and Rheumatism, vol. 33, no. 5, pp. 634–643, 1990. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Reichlin, T. F. Broyles, O. Hubscher et al., “Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease,” Arthritis and Rheumatism, vol. 42, no. 1, pp. 69–75, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Malik, G. R. Bruner, C. Williams-Weese et al., “Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients,” Lupus, vol. 16, no. 11, pp. 863–866, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. V. D. Pradhan, S. S. Badakere, L. S. Bichile, and M. P. Dolas, “Antibodies to Ro/SS-A and La/SS-B in systemic lupus erythematosus and other autoimmune disorders,” Journal of Association of Physicians of India, vol. 50, no. 6, pp. 762–765, 2002. View at Google Scholar · View at Scopus
  18. T. Grader-Beck and F. M. Wigley, “Raynaud's phenomenon in mixed connective tissue disease,” Rheumatic Disease Clinics of North America, vol. 31, no. 3, pp. 465–481, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. G. A. McCarty, J. B. Harley, and M. Reichlin, “A distinctive autoantibody profile in black female patients with lupus nephritis,” Arthritis and Rheumatism, vol. 36, no. 11, pp. 1560–1565, 1993. View at Publisher · View at Google Scholar · View at Scopus
  20. C. E. Tseng, J. P. Buyon, M. Kim et al., “The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial,” Arthritis and Rheumatism, vol. 54, no. 11, pp. 3623–3632, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. T. McClain, M. R. Arbuckle, L. D. Heinlen et al., “The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 50, no. 4, pp. 1226–1232, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. E. M. Tan, A. S. Cohen, and J. F. Fries, “The 1982 revised criteria for the classification of systemic lupus erythrematosus,” Arthritis and Rheumatism, vol. 25, no. 11, pp. 1271–1277, 1982. View at Google Scholar · View at Scopus
  23. M. C. Hochberg, “Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 40, no. 9, p. 1725, 1997. View at Google Scholar · View at Scopus
  24. A. Rasmussen, S. Sevier, J. A. Kelly et al., “The lupus family registry and repository,” Rheumatology, vol. 50, no. 1, pp. 47–59, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. T. McClain, L. D. Heinlen, G. J. Dennis, J. Roebuck, J. B. Harley, and J. A. James, “Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry,” Nature Medicine, vol. 11, no. 1, pp. 85–89, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. S. R. Binder, M. C. Genovese, J. T. Merrill, R. I. Morris, and A. L. Metzger, “Computer-assisted pattern recognition of autoantibody results,” Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 12, pp. 1353–1357, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. B. F. Bruner, J. M. Guthridge, R. Lu et al., “Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of SLE patients and family members,” Arthritis and Rheumatism. In press.
  28. N. Bardin, S. Desplat-Jego, L. Daniel, N. Jourde Chiche, and M. Sanmarco, “BioPlex 2200 multiplexed system: simultaneous detection of anti-dsDNA and anti-chromatin antibodies in patients with systemic lupus erythematosus,” Autoimmunity, vol. 42, no. 1, pp. 63–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. G. Hanly, L. Su, V. Farewell, and M. J. Fritzler, “Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus,” Journal of Immunological Methods, vol. 358, no. 1-2, pp. 75–80, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. J. G. Hanly, K. Thompson, G. McCurdy, L. Fougere, C. Theriault, and K. Wilton, “Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus,” Journal of Immunological Methods, vol. 352, no. 1-2, pp. 147–152, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. K. G. Moder, M. H. Wener, M. H. Weisman et al., “Measurement of antinuclear antibodies by multiplex immunoassay: a prospective, multicenter clinical evaluation,” Journal of Rheumatology, vol. 34, no. 5, pp. 978–986, 2007. View at Google Scholar · View at Scopus
  32. O. Shovman, B. Gilburd, O. Barzilai et al., “Evaluation of the BioPlex 2200 ANA screen. Analysis of 510 healthy subjects: incidence of natural/predictive autoantibodies,” Annals of the New York Academy of Sciences, vol. 1050, pp. 380–388, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. C. S. Lau, G. Yin, and M. Y. Mok, “Ethnic and geographical differences in systemic lupus erythematosus: an overview,” Lupus, vol. 15, no. 11, pp. 715–719, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Kumar, S. Chambers, and C. Gordon, “Challenges of ethnicity in SLE,” Best Practice and Research, vol. 23, no. 4, pp. 549–561, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. A. I. Quintero-Del-Rió, D. Bacino, J. Kelly, T. Aberle, and J. B. Harley, “Familial systemic lupus erythematosus: a comparison of clinical manifestations and antibody presentation in three ethnic groups,” Cellular and Molecular Biology, vol. 47, no. 7, pp. 1223–1227, 2001. View at Google Scholar · View at Scopus
  36. D. L. Kamen, M. Barron, T. M. Parker et al., “Autoantibody prevalence and lupus characteristics in a unique African American population,” Arthritis and Rheumatism, vol. 58, no. 5, pp. 1237–1247, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. C. H. To and M. Petri, “Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus?” Arthritis and Rheumatism, vol. 52, no. 12, pp. 4003–4010, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. M. A. Nalls, J. G. Wilson, N. J. Patterson et al., “Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies,” American Journal of Human Genetics, vol. 82, no. 1, pp. 81–87, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Reich, M. A. Nalls, W. H. L. Kao et al., “Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene,” PLoS Genetics, vol. 5, no. 1, p. e1000360, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. A. P. Reiner, G. Lettre, M. A. Nalls et al., “Genome-Wide association study of white blood cell count in 16,388 african americans: the continental Origins and Genetic Epidemiology network (COGENT),” PLoS Genetics, vol. 7, no. 6, p. e1002108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. T. B. Haddy, S. R. Rana, and O. Castro, “Benign ethnic neutropenia: what is a normal absolute neutrophil count?” Journal of Laboratory and Clinical Medicine, vol. 133, no. 1, pp. 15–22, 1999. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Alba, L. Bento, M. J. Cuadrado et al., “Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis,” Annals of the Rheumatic Diseases, vol. 62, no. 6, pp. 556–560, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. G. S. Cooper, C. G. Parks, E. L. Treadwell et al., “Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States,” Lupus, vol. 11, no. 3, pp. 161–167, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. A. L. Sestak, S. K. Nath, J. A. Kelly, G. R. Bruner, J. A. James, and J. B. Harley, “Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race,” Lupus, vol. 17, no. 11, pp. 1004–1009, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. W. X. Li, H. F. Pan, L. H. Li et al., “Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus,” Irish Journal of Medical Science, vol. 179, no. 4, pp. 623–627, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. X. Tang, Y. Huang, W. Deng, L. Tang, W. Weng, and X. Zhang, “Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China,” Medicine, vol. 89, no. 1, pp. 62–67, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. W. X. Li, H. F. Pan, L. H. Li et al., “Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus,” Irish Journal of Medical Science, vol. 179, no. 4, pp. 623–627, 2010. View at Publisher · View at Google Scholar · View at Scopus