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Autoimmune Diseases
Volume 2012, Article ID 876456, 4 pages
Review Article

Vascular Disease in Systemic Lupus Erythematosus

2nd Propedeutic Department of Internal Medicine, Hippokration General Hospital, Konstantinoupoleos 49, 54643 Thessaloniki, Greece

Received 29 April 2012; Accepted 3 August 2012

Academic Editor: Tatiana S. Rodriguez-Reyna

Copyright © 2012 Athina Pyrpasopoulou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vascular disease, either as a direct complication of the disease or developing as an accompanying comorbidity impairs significantly the quality of life of patients with SLE and represents the most frequent cause of death in established lupus. This paper aims to give an overview of the prevalence of the different forms of vasculopathy that can be encountered in a lupus patient, describe their pathogenesis, and address their impact on disease severity and outcome.