Total Knee Arthroplasty Considerations in Rheumatoid Arthritis

Table 2

Literature review of DMARD safety in the perioperative period.

	Medication	Patients	Infections	Flares
	Methotrexate
[15]	Continued	88	2 (2%)	0
	Held Medication∧	72	11 (15%)	6 (8%)
	Other DMARD/steroid	228	24 (11%)	9 (4)
	TNF-α Inhibitor*
[17]	Etanercept	33	0	—
	Infliximab	22	1 (5%)	—
	Adalimumab	3	0	—

∧Methotrexate was held two weeks before until two weeks after surgery in this group. *Etanercept and adalimumab were held two weeks before until two weeks after surgery, while infliximab was held both four weeks prior to and after surgery.