Immunosenescence, Aging, and Systemic Lupus Erythematous

Figure 2

Changes in the T-cell pool and individual cells during aging. A Proportion of T subsets depends on individual infection antecedents and the environment. Memory T-cell subset can change to senescence by a chronic latent infection and chronic TCR stimulation. Meanwhile, exhausted T cells are produced by the same type of stimulation and the chronic acute infection. Aged naïve cells are generated from naïve cells stimulated by self-antigen exposure (adapted from [32]).