Composite Indices Using 3 or 4 Components of the Core Data Set Have Similar Predictive Ability to Measure Disease Activity in RA: Evidence from the DANCER and REFLEX Studies

Figure 1

Combinations of RA Core Data Set measures used to derive Composite Efficacy Indices. *Measured using the Health Assessment Questionnaire. For comparison, DAS28, CDAI, and RAPID3 are derived using different formulae. DAS28 includes 4 RA Core Data Set measures (TJC, SJC, CRP (or ESR), and PATGL) from three sources. CDAI includes four RA Core Data Set measures (TJC, SJC, DOCGL, and PATGL) from two sources. RAPID3 includes three RA Core Data Set measures (PATGL, PAIN, and FN) from one source. CDAI: Clinical Disease Activity Index; CRP: C-reactive protein; DAS28: Disease Activity Score in 28 joints; DOCGL: assessor global; ESR: erythrocyte sedimentation rate; FN: physical function; PAIN: pain; PATGL: patient global estimate; RAPID3: Routine Assessment of Patient Index Data 3; SJC: swollen joint count; TJC: tender joint count.