Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels

Table 5

Age-Adjusted, log-normalized correlations (Pearson) of hormones in higher-level cortisol pre-RA (top) and CN (bottom) females*.

Hormones		Preg	Prog	17-OHpreg	17-OHprog	DHEA	Adione	Test	Estradiol	Estrone	Cmpd B	DeoxyCort	Cortisol	DHEAS
Preg	𝑟		0.568	0.085	0.485	−0.125	−0.209	−0.201	0.040	0.016	−0.272	0.286	−𝟎.𝟒𝟔𝟗^†	−0.310
	𝑝		0.011	0.722	0.030	0.621	0.404	0.408	0.880	0.970	0.246	0.222	𝟎.𝟎𝟑𝟕	0.183
	𝑛		20	21	21	19	19	20	18	9	21	21	𝟐𝟏	21
Prog	𝑟	0.361		0.265	0.689	−0.016	0.021	−0.532	0.499	−0.097	0.100	0.228	−0.485	0.014
	𝑝	0.006		0.273	0.001	0.950	0.936	0.023	0.049	0.820	0.659	0.308	0.022	0.952
	𝑛	57		20	20	18	18	19	17	9	23	23	23	23
17-OHpreg	𝑟	0.441	0.324		0.660	0.842 *	0.775	0.182	−0.032	0.279	0.183	0.095	−0.084	0.468
	𝑝	0.001	0.015		0.002	0.000	0.000	0.456	0.904	0.504	0.439	0.691	0.725	0.037
	𝑛	57	57		21	19	19	20	18	9	21	21	21	21
17-OHprog	𝑟	0.456	0.625	0.728		0.409	0.443	−0.408	0.114	−0.004	0.041	0.234	−0.516	0.232
	𝑝	0.000	0.000	0.000		0.092	0.066	0.083	0.662	0.992	0.864	0.320	0.020	0.324
	𝑛	57	57	57		19	19	20	18	9	21	21	21	21
DHEA	𝑟	0.173	0.003	0.575	0.464		0.734	0.192	−0.263	0.333	0.167	0.129	−0.046	0.535
	𝑝	0.210	0.981	0.000	0.000		0.001	0.446	0.343	0.519	0.508	0.611	0.857	0.022
	𝑛	55	55	55	55		19	19	16	7	19	19	19	19
Adione	𝑟	0.252	0.070	0.405	0.333	0.736		−0.006	−0.020	0.306	0.106	−0.099	−0.098	0.741
	𝑝	0.066	0.617	0.002	0.014	0.000		0.980	0.943	0.556	0.677	0.696	0.699	0.000
	𝑛	55	55	55	55	55		19	16	7	19	19	19	19
Test	𝑟	−0.078	−0.260	0.265	−0.112	0.393	0.232		−0.386	−0.216	0.093	0.103	0.292	0.113
	𝑝	0.586	0.065	0.060	0.434	0.004	0.101		0.140	0.642	0.705	0.676	0.225	0.647
	𝑛	52	52	52	52	52	52		17	8	20	20	20	20
Estradiol	𝑟	0.281	0.301	0.193	0.320	0.226	0.331	−0.043		0.739	−0.228	−0.109	−0.144	0.018
	𝑝	0.051	0.036	0.184	0.025	0.126	0.023	0.780		0.036	0.378	0.678	0.581	0.947
	𝑛	50	50	50	50	48	48	45		9	18	18	18	18
Estrone	𝑟	0.125	0.250	−0.196	0.040	0.146	0.060	0.064	0.402		−𝟎.𝟕𝟓𝟏^∗	−𝟎.𝟔𝟕𝟔^∗	−0.075	−0.061
	𝑝	0.543	0.218	0.338	0.848	0.497	0.782	0.782	0.042		𝟎.𝟎𝟑𝟐	𝟎.𝟎𝟔𝟔	0.861	0.886
	𝑛	27	27	27	27	25	25	22	27		𝟗	𝟗	9	9
Cmpd B	𝑟	0.290	0.165	0.147	0.015	−0.158	0.038	0.088	0.117	𝟎.𝟎𝟒𝟓		0.612	0.382	0.020
	𝑝	0.030	0.175	0.280	0.911	0.253	0.787	0.541	0.424	𝟎.𝟖𝟐𝟖		0.002	0.072	0.928
	𝑛	57	70	57	57	55	55	52	50	𝟐𝟕		24	24	24
DeoxyCort	𝑟	0.211	0.186	0.023	0.051	−0.087	0.009	−0.082	0.341	𝟎.𝟐𝟏𝟕	0.631		−0.109	−0.101
	𝑝	0.118	0.125	0.865	0.711	0.531	0.947	0.566	0.016	𝟎.𝟐𝟖𝟔	0.000		0.620	0.646
	𝑛	57	70	57	57	55	55	52	50	𝟐𝟕	71		24	24
Cortisol	𝑟	𝟎.𝟏𝟖𝟔	−0.244	0.058	−0.274	−0.072	−0.036	0.307	−0.125	−0.252	0.292	0.148		−0.249
	𝑝	𝟎.𝟏𝟔𝟗	0.043	0.669	0.041	0.606	0.798	0.028	0.394	0.214	0.014	0.222		0.252
	𝑛	𝟓𝟕	70	57	57	55	55	52	50	27	71	71		24
DHEAS	𝑟	0.174	−0.078	0.124	0.139	0.482	𝟎.𝟓𝟏𝟕	0.025	0.139	0.386	−0.035	0.006	−0.222
	𝑝	0.201	0.525	0.362	0.309	0.000	𝟎.𝟎𝟎𝟎	0.863	0.341	0.052	0.772	0.962	0.065
	𝑛	57	70	57	57	55	𝟓𝟓	52	50	27	71	71	71

∗Significant differences between pre-RA versus CN correlations, when requiring both adjusted and set-specific Z-score values to combine assay results.
Symbols placed at the greater 𝑟 values: ^∗𝑃≤0.050; ^†𝑃≤0.010.