Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies
Table 2
Univariate analysis comparing clinical features between SLE patients with low (<2) FCGR3B and ≥2 FCGR3B gene copy number. Figures indicate mean values or number of patients (percentage). values derive from Mann-Whitney U test and chi-square testing as appropriate.
FCGR3B < 2 ()
FCGR3B ≥ 2 ()
value
Age (yrs)
43.3
47.9
0.3
Female gender (%)
18 (86)
77 (90)
0.47
Disease duration (months)
162
151
0.7
Organ damage present (SDI > 0)
60
58
0.9
SLEDAI-2K score
10.4
6.1
0.03
LN present (%)
5 (24)
6 (6.9)
0.03
Arthritis present (%)
4 (19)
9 (11)
0.3
Active skin lesions present (%)
2 (10)
3 (4)
0.4
Leukocytopenia (<4)
3 (14)
18 (21)
0.3
Anti-dsDNA positive
8 (38)
16 (18)
0.05
Anti-dsDNA titer ( < 55 IU)
81
37
0.03
Anti-C1q positive
6 (29)
10 (12)
0.06
Anti-C1q titer ( < 11 IU)
22
5.5
0.003
Antiribosomal P positive
4 (19)
6 (7)
0.1
Antiribosomal P titer ( < 8 IU)
10
5
0.01
Anti-Ro positive (%)
43
36
0.62
Anti-Sm positive (%)
5
6
0.9
Low C3 (<81 mg/dL) (%)
30
28
0.9
SLEDAI-2K: SLE Disease Activity Index-2000 version, SDI: SLICC-ACR Damage Index, LN: lupus nephritis (see methods for definition), and C3: complement factor 3.
