Genome-Wide Association Study of Antiphospholipid Antibodies
Table 4
Genetic loci associated with the occurrence of anti-GPI antibodies with *.
CHR
Gene
Lead SNP
BP
Total SNPs
MAF
OR
Negative
Positive
13
MYO16
rs10492418
108178727
5
0.4292
0.6016
2.172
7
PDE1C
rs11975235
32156065
4
0.4843
0.311
0.4675
2
TANK
rs2357982
161594349
13
0.2359
0.3885
2.189
13
FLJ42392
rs9315762
39639907
2
0.1535
0.2901
2.255
20
MACROD2
rs6080100
15951406
7
0.2655
0.4275
2.086
17
CAMKK1
rs758642
3733656
1
0.3314
0.4837
2.038
14
ITPK1
rs8021497
92637371
6
0.2059
0.3508
2.101
2
SESTD1
rs10186547
179921914
2
0.3853
0.5391
2.009
10
CACNB2
rs12356676
18687510
6
0.2587
0.3943
2.134
18
LRRC30
rs9965173
7201755
4
0.07887
0.1718
2.647
3
PEX5L
rs9856007
181225431
3
0.2514
0.3817
1.976
11
TMEM45B
rs10894119
129081436
1
0.1835
0.293
2.168
10
SFTA1P
rs1000039
10597879
1
0.02254
0.08779
4.19
9
OR1J1
rs2778636
124270913
2
0.2641
0.3931
1.955
5
RAPGEF6
rs17671387
130911895
1
0.04507
0.1183
3.186
2
GMCL1
rs4241261
69917164
3
0.4761
0.3308
0.5278
14
C14orf101
rs7153196
56256660
2
0.362
0.229
0.4996
9
WNK2
rs10821084
94991443
1
0.07627
0.1718
2.425
10
SLC16A9
rs7082987
61007793
1
0.3663
0.2317
0.4886
4
GDEP
rs11730315
81020089
2
0.1648
0.2829
2.075
4
ARHGAP24
rs17010960
86938938
2
0.02254
0.07634
4.326
13
HTR2A
rs582385
46343995
4
0.1624
0.2824
2.02
15
FMN1
rs2444955
31199305
2
0.2211
0.355
1.974
5
CARTPT
rs16869487
70976850
1
0.02841
0.09542
3.602
2
NEU2
rs11695991
233608333
1
0.0169
0.0687
4.802
17
CA10
rs203076
47354484
7
0.2944
0.1603
0.4729
9
C9orf135
rs1389124
71669176
3
0.09943
0.1985
2.286
20
SMOX
rs1764996
4070805
2
0.02817
0.07634
4.014
CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with in the gene region; MAF: minor allele frequencies in antibody-negative and antibody-positive groups; OR: odds ratio; : -values for the test.
