Genome-Wide Association Study of Antiphospholipid Antibodies
Table 6
Significant SNPs with in the MHC region on chromosome 6 for ACL, LAC, and Anti-GP1*.
Gene
SNP
P
ACL
HLA-DPB1
rs3128918
0.00028
HLA-DPB2
rs2395357
0.00043
HLA-DMA
rs11539216
0.00099
HLA-DQB2
rs10484564
0.00536
GNL1
rs9295888
0.00758
GNL1
rs9295873
0.00794
HLA-DOA
rs4713603
0.0081
RPP21
rs1548515
0.00842
GNL1
rs9461607
0.00863
GNL1
rs17411480
0.00863
RPP21
rs9261821
0.00863
RPP21
rs9261850
0.00863
RPP21
rs9261854
0.00863
RPP21
rs9261855
0.00863
RPP21
rs1548513
0.00863
RPP21
rs9261925
0.00863
RPP21
rs9261926
0.00863
BRD2
rs17840186
0.00939
RPP21
rs9261799
0.00955
LAC
TAP2
rs1044043
0.00029
HLA-DQA1
rs642093
0.00032
AIF1
rs2736177
0.00041
HLA-DQA2
rs9275765
0.00078
HLA-DQA2
rs9275772
0.00078
HLA-DQA2
rs9275793
0.00088
HLA-DQA1
rs9272346
0.00130
HLA-DQA2
rs9276298
0.00133
HLA-DQA1
rs9272219
0.00167
C6orf10
rs3129934
0.00168
HLA-DQA1
rs9272535
0.00179
HLA-DRB1
rs674313
0.00215
HLA-DRB1
rs502771
0.00227
HLA-DRB1
rs9270986
0.00250
AIF1
rs2857597
0.00257
HCG26
rs2516516
0.00282
HLA-DRB1
rs615672
0.00295
HLA-DRB1
rs502055
0.00300
HLA-DQA1
rs9272723
0.00329
LOC100294145
rs9276915
0.00352
C6orf10
rs2894254
0.00372
UBD
rs9368606
0.00403
C6orf10
rs3129900
0.00458
MCCD1
rs2734573
0.00553
PRRC2A
rs1046080
0.00618
C6orf10
rs7767325
0.00623
C6orf15
rs2517448
0.00627
C6orf10
rs3132928
0.00640
HLA-H
rs3132722
0.00675
HLA-DQB2
rs2857210
0.00685
HLA-DRA
rs3129868
0.00731
ATP6V1G2-DDX39B/DDX39B
rs933208
0.00740
NFKBIL1
rs2857605
0.00755
TRIM26
rs3132671
0.00757
HLA-DQB1
rs3129716
0.00770
MSH5/MSH5-C6orf26
rs3131379
0.00849
MSH5/MSH5-C6orf26
rs3130484
0.00901
PSMB9
rs9276832
0.00907
BTNL2
rs2213581
0.00922
HLA-DMA
rs11539216
0.00929
ATP6V1G2-DDX39B/DDX39B
rs3093978
0.00957
C6orf10
rs2143461
0.00986
TUBB
rs3095330
0.00990
LOC100294145
rs4959119
0.00992
TRIM26
rs2517611
0.00993
Anti-GPI
HLA-DPB2
rs9277916
0.00147
HLA-DQA2
rs9275793
0.00310
HLA-DQA2
rs9275765
0.00315
HLA-DQA2
rs9275772
0.00315
HLA-DPA1
rs3130182
0.00331
HLA-DQB1
rs9469220
0.00372
HLA-DPB2
rs4711314
0.00378
HLA-DQA2
rs2647089
0.00463
HLA-DQA2
rs9276298
0.00523
HLA-DQB1
rs9275356
0.00526
HLA-DQA2
rs17615250
0.00710
HLA-DQA2
rs9275618
0.00807
ACL: anticardiolipin antibodies; LAC: lupus anticoagulant; Anti-GPI: anti- glycoprotein I antibodies; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the SNP; SNP: single-nucleotide polymorphism; : -values for the test.
