B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity—Focus on Systemic Lupus Erythematosus

Figure 3

B cell classification based on their ontogenic state. From the transitional type 1 (T1) and T2 B cells, two options depend on the B cell receptor (BCR) evoked signal and the downstream Notch 2 proteins: germinal center (GC) B cells driven by the B cell-attracting (BCA)-1 chemokine (or CXCL13) and MZ B cells with mutations but without activation-induced cytidine deaminase (AID). (Modified from [10]).