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Autoimmune Diseases
Volume 2014 (2014), Article ID 237107, 8 pages
http://dx.doi.org/10.1155/2014/237107
Research Article

Anti-Transglutaminase 6 Antibodies in Children and Young Adults with Cerebral Palsy

Reidun Stenberg,1 Marios Hadjivassiliou,2 Pascale Aeschlimann,3 Nigel Hoggard,2 and Daniel Aeschlimann3

1Department of Pediatrics, Centre for Rehabilitation Research and Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, 70185 Örebro, Sweden
2Department of Neurology and Department of Neuroradiology, The Royal Hallamshire Hospital, Sheffield S10 2JF, UK
3Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff CF14 4XY, UK

Received 18 November 2013; Revised 10 February 2014; Accepted 17 February 2014; Published 2 April 2014

Academic Editor: Kalle Kurppa

Copyright © 2014 Reidun Stenberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Himmelmann, E. Beckung, G. Hagberg, and P. Uvebrant, “Bilateral spastic cerebral palsy—prevalence through four decades, motor function and growth,” European Journal of Paediatric Neurology, vol. 11, no. 4, pp. 215–222, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. O. Dahlseng, A.-K. Finbråten, P. B. Júlíusson, J. Skranes, G. Andersen, and T. Vik, “Feeding problems, growth and nutritional status in children with cerebral palsy,” Acta Paediatrica, vol. 101, no. 1, pp. 92–98, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Bax, C. Tydeman, and O. Flodmark, “Clinical and MRI correlates of cerebral palsy: the European cerebral palsy study,” Journal of the American Medical Association, vol. 296, no. 13, pp. 1602–1608, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. W. Wu, G. J. Escobar, J. K. Grether, L. A. Croen, J. D. Greene, and T. B. Newman, “Chorioamnionitis and cerebral palsy in term and near-term infants,” Journal of the American Medical Association, vol. 290, no. 20, pp. 2677–2684, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. A. T. Pakula, K. Van Naarden Braun, and M. Yeargin-Allsopp, “Cerebral palsy: classification and epidemiology,” Physical Medicine and Rehabilitation Clinics of North America, vol. 20, no. 3, pp. 425–452, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Stenberg, C. Dahle, E. Lindberg, and J. Schollin, “Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy,” Journal of Pediatric Gastroenterology and Nutrition, vol. 49, no. 4, pp. 424–429, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Stenberg, C. Dahle, A. Magnuson, and D. Hellberg, “Increased prevalence of antibodies against dietary proteins in children and young adults with cerebral palsy,” Journal of Pediatric Gastroenterology and Nutrition, vol. 56, no. 2, pp. 233–238, 2013. View at Google Scholar
  8. U. Volta, F. Tovoli, R. Cicola et al., “Serological tests in gluten sensitivity (nonceliac gluten intolerance),” Journal of Clinical Gastroenterology, vol. 46, no. 8, pp. 680–685, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Stenberg and J. Schollin, “Is there a connection between severe cerebral palsy and increased gluten sensitivity?” Acta Paediatrica, vol. 96, no. 1, pp. 132–134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Stenberg, K. Kaukinen, M. Bengtsson, E. Lindberg, and C. Dahle, “Early developing celiac disease in children with cerebral palsy,” Journal of Pediatric Gastroenterology and Nutrition, vol. 53, no. 6, pp. 674–678, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Palisano, P. Rosenbaum, S. Walter, D. Russell, E. Wood, and B. Galuppi, “Development and reliability of a system to classify gross motor function in children with cerebral palsy,” Developmental Medicine and Child Neurology, vol. 39, no. 4, pp. 214–223, 1997. View at Google Scholar · View at Scopus
  12. M. Sárdy, S. Kárpáti, B. Merkl, M. Paulsson, and N. Smyth, “Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis,” Journal of Experimental Medicine, vol. 195, no. 6, pp. 747–757, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Hadjivassiliou, S. Boscolo, G. A. B. Davies-Jones et al., “The humoral response in the pathogenesis of gluten ataxia,” Neurology, vol. 58, no. 8, pp. 1221–1226, 2002. View at Google Scholar · View at Scopus
  14. M. Hadjivassiliou, M. Mäki, D. S. Sanders et al., “Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia,” Neurology, vol. 66, no. 3, pp. 373–377, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Hadjivassiliou, D. S. Sanders, R. A. Grünewald, N. Woodroofe, S. Boscolo, and D. Aeschlimann, “Gluten sensitivity: from gut to brain,” The Lancet Neurology, vol. 9, no. 3, pp. 318–330, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Hadjivassiliou, P. Aeschlimann, A. Strigun, D. S. Sanders, N. Woodroofe, and D. Aeschlimann, “Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase,” Annals of Neurology, vol. 64, no. 3, pp. 332–343, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Thomas, K. Beck, M. Adamczyk et al., “Transglutaminase 6: a protein associated with central nervous system development and motor function,” Amino Acids, vol. 44, no. 1, pp. 161–177, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Mutch, E. Alberman, B. Hagberg, K. Kodama, and M. V. Perat, “Cerebral palsy epidemiology: where are we now and where are we going?” Developmental Medicine and Child Neurology, vol. 34, no. 6, pp. 547–551, 1992. View at Google Scholar · View at Scopus
  19. B. Hagberg, G. Hagberg, and I. Olow, “The changing panorama of cerebral palsy in Sweden 1954-1970. I. Analysis of the general changes,” Acta Paediatrica Scandinavica, vol. 64, no. 2, pp. 187–192, 1975. View at Google Scholar · View at Scopus
  20. K. Albertsson-Wikland and J. Karlberg, “Natural growth in children born small for gestational age with and without catch-up growth,” Acta Paediatrica, Supplement, vol. 83, no. 399, pp. 64–71, 1994. View at Google Scholar · View at Scopus
  21. K. Karell, A. S. Louka, S. J. Moodie et al., “HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European genetics cluster on celiac disease,” Human Immunology, vol. 64, no. 4, pp. 469–477, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Bodd, S. Tollefsen, E. Bergseng, K. E. A. Lundin, and L. M. Sollid, “Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells,” Human Immunology, vol. 73, no. 4, pp. 376–381, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Hadjivassiliou, P. Aeschlimann, D. S. Sanders et al., “Transglutaminase 6 antibodies in the diagnosis of gluten ataxia,” Neurology, vol. 80, no. 19, pp. 1740–1745, 2013. View at Publisher · View at Google Scholar
  24. J. Stamnaes, S. Dorum, B. Fleckenstein, D. Aeschlimann, and L. M. Sollid, “Gluten T cell epitope targeting by TG3 and TG6; Implications for dermatitis herpetiformis and gluten ataxia,” Amino Acids, vol. 39, no. 5, pp. 1183–1191, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. P. G. Lunn, C. A. Northrop-Clewes, and R. M. Downes, “Intestinal permeability, mucosal injury, and growth faltering in Gambian infants,” The Lancet, vol. 338, no. 8772, pp. 907–910, 1991. View at Publisher · View at Google Scholar · View at Scopus
  26. P. G. Lunn, “The impact of infection and nutrition on gut function and growth in childhood,” Proceedings of the Nutrition Society, vol. 59, no. 1, pp. 147–154, 2000. View at Google Scholar · View at Scopus
  27. A. K. Dimitrova, R. C. Ungaro, B. Lebwohl et al., “Prevalence of migraine in patients with celiac disease and inflammatory bowel disease,” Headache, vol. 53, no. 2, pp. 344–355, 2013. View at Google Scholar
  28. R. Francavilla, F. Cristofori, S. Castellaneta et al., “Clinical, serologic, and histologic features of gluten sensitivity in children,” Journal of Pediatrics, vol. 164, no. 3, pp. 463–467, 2013. View at Publisher · View at Google Scholar
  29. M. Hadjivassiliou, R. A. Grünewald, M. Lawden, G. A. B. Davies-Jones, T. Powell, and C. M. L. Smith, “Headache and CNS white matter abnormalities associated with gluten sensitivity,” Neurology, vol. 56, no. 3, pp. 385–388, 2001. View at Google Scholar · View at Scopus
  30. S. Currie, M. Hadjivassiliou, M. J. Clark et al., “Should we be “nervous” about coeliac disease? Brain abnormalities in patients with coeliac disease referred for neurological opinion,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 83, no. 12, pp. 1216–1221, 2012. View at Google Scholar
  31. J. F. Ludvigsson and M. Hadjivassiliou, “Can head trauma trigger celiac disease? Nation-wide case-control study,” BMC Neurology, vol. 13, p. 105, 2013. View at Google Scholar
  32. S. Boscolo, A. Lorenzon, D. Sblattero et al., “Anti transglutaminase antibodies cause ataxia in mice,” PloS ONE, vol. 5, no. 3, Article ID e9698, 2010. View at Google Scholar · View at Scopus
  33. J. Wang, J. L. Wang, X. Yang et al., “TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing,” Brain, vol. 133, no. 12, pp. 3510–3518, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Li, S. Y. Pang, Y. Song, M. H. Kung, S. L. Ho, and P. C. Sham, “Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family,” Clinical Genetics, vol. 83, no. 3, pp. 269–273, 2013. View at Google Scholar