Neuroantibody Biomarkers: Links and Challenges in Environmental Neurodegeneration and Autoimmunity
Figure 3
Serum titers of IgG against AChE, the enzyme responsible for acetylcholine hydrolysis, in hens () administered a single dose of OPIDP-inducing phenyl saligenin phosphate (PSP, 2.5 mg/kg, im). Serum was collected at 7, 14, and 21 days. Mean levels of IgG (±S.E.) were significantly (∗) higher at 14 and 21 days compared to 7 days and at 21 days compared to 14 days (∗∗). Although OPIDP development is believed to be independent of AChE inhibition, some organophosphates may induce acute inhibition and phosphorylation of the enzyme.
