Research Article
Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
Table 3
Overview of the cell responses to tested DQ2 and DQ8 gliadin epitopes.
Peripheral cell responses as measured by CD4+CFSElo proliferated cells for each individual with correlation to HLA-DQ genotype. Black boxes represent a response to the peptide with the SI ≥ 3. Gliadin epitopes are denoted as previously reported in the literature to be presented by HLA-DQ2 (-I gliadin QLQPFPQPELPY, -II gliadin PQPELPYPQPQL, and gliadin PEQPQQSFPEQERP) or HLA-DQ8 (-gliadin SGQGSFQPSQQNP and -gliadin FPQQPQQPYPQQPQQ with and without deamidation at p1 and p9). Three of the new-onset CD children responding to two or more peptides have the DQ2/2 genotype. |