Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies

Table 1

Summary of immunological parameters associated with vitiligo treatments reported in the literature.

Author	Type of vitiligo	Treatment	Main findings in immunological parameters	Reference
Rao et al.	Generalized	Surgical by suction blister epidermal grafting	Patients with active vitiligo and poor treatment response had increased levels of CD8+ and CD45RO+ cells in skin lesions	[30]
Abdallah et al.	Generalized	Surgical by autologous minigrafting	Patients unresponsive to treatment had increased cytotoxic T lymphocyte in skin lesions	[31]
Zhou et al.	Localized and generalized	Surgical by autologous melanocyte transplantation	Patients with poor repigmentation response had higher levels of CD8+ T cells in perilesional skin and increased levels of proinflammatory cytokines in epidermis fluid	[32]
Reyes et al.	Generalized	PUVA and Polypodium leucotomos	Abnormal activation and decrease in CD8+CD45RO+ blood lymphocytes	[33]
Antelo et al.	Generalized	PUVA	Reduction of CD8+CLA+ lymphocytes in peripheral blood	[34]
Shi et al.	Vitiligo with qi-stagnancy and blood-stasis	Chinese herbs Zengse pill combined with cobalamin and psoralea tincture	Increased CD4/CD8 ration and reduced CD8+ in peripheral blood	[35]
Tembhre et al.	Generalized	NB-UVB	Increased serum IL-10, IL-13, and IL-17 and decreased TGF-β in active vitiligo patients. NB-UVB may be able to modulate T helper and Treg cytokines.	[36]
Moftah et al.	Generalized	NB-UVB	NB-UVB treatment decreased peripheral blood Treg cells.	[37]