Autoimmune Diseases / 2015 / Article / Tab 1

Review Article

Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies

Table 1

Summary of immunological parameters associated with vitiligo treatments reported in the literature.

AuthorType of vitiligoTreatmentMain findings in immunological parametersReference

Rao et al.GeneralizedSurgical by suction blister epidermal graftingPatients with active vitiligo and poor treatment response had increased levels of CD8+ and CD45RO+ cells in skin lesions[30]

Abdallah et al.GeneralizedSurgical by autologous minigraftingPatients unresponsive to treatment had increased cytotoxic T lymphocyte in skin lesions[31]

Zhou et al.Localized and generalizedSurgical by autologous melanocyte transplantationPatients with poor repigmentation response had higher levels of CD8+ T cells in perilesional skin and increased levels of proinflammatory cytokines in epidermis fluid[32]

Reyes et al.GeneralizedPUVA and Polypodium leucotomosAbnormal activation and decrease in CD8+CD45RO+ blood lymphocytes[33]

Antelo et al.GeneralizedPUVAReduction of CD8+CLA+ lymphocytes in peripheral blood[34]

Shi et al.Vitiligo with qi-stagnancy and blood-stasisChinese herbs Zengse pill combined with cobalamin and psoralea tinctureIncreased CD4/CD8 ration and reduced CD8+ in peripheral blood[35]

Tembhre et al.GeneralizedNB-UVBIncreased serum IL-10, IL-13, and IL-17 and decreased TGF-β in active vitiligo patients. NB-UVB may be able to modulate T helper and Treg cytokines.[36]

Moftah et al.GeneralizedNB-UVBNB-UVB treatment decreased peripheral blood Treg cells.[37]