Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study

Table 6

Area under the curve (AUC) of ROC curves for uMCP-1 and standard biomarkers for LN activity on longitudinal follow-up.

Variables	Baseline (95% CI)				2 months (95% CI)				4 months (95% CI)
	AUC		LB	UB	AUC		LB	UB	AUC		LB	UB
uMCP-1	0.82	0.001	0.73	0.91	0.82	<0.001	0.73	0.90	0.87	<0.001	0.78	0.95
Serum; albumin	0.25	0.001	0.13	0.35	0.23	<0.001	0.13	0.33	0.21	<0.001	0.10	0.31
Serum; creatinine	0.58	0.21	0.44	0.71	0.55	0.42	0.41	0.69	0.68	0.009	0.54	0.82
eGFR	0.41	0.21	0.28	0.55	0.42	0.22	0.28	0.55	0.31	0.01	0.17	0.45
Anti-dsDNA; Ab titres	0.50	0.96	0.37	0.63	0.49	0.78	0.35	0.62	0.56	0.46	0.38	0.73
Serum C3	0.37	0.50	0.25	0.50	0.45	0.84	0.33	0.57	0.40	0.21	0.25	0.54
Serum C4	0.43	0.26	0.30	0.56	0.42	0.22	0.29	0.54	0.45	0.53	0.29	0.61
Proteinuria (uPCI)	0.94	<0.001	0.89	0.98	0.92	<0.001	0.86	0.99	0.89	<0.001	0.80	0.98
Haematuria	0.72	0.001	0.60	0.84	0.54	0.49	0.41	0.67	0.62	0.07	0.48	0.77
Leukocyturia	0.65	0.23	0.52	0.77	0.54	0.51	0.41	0.67	0.62	0.08	0.47	0.77
SLEDAI-2K (renal score)	0.96	<0.001	0.71	0.90	0.84	<0.001	0.76	0.93	0.85	<0.001	0.77	0.94