Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease

<div>Risk gradient according to HLA haplotype combinations, considering a disease prevalence of 1 : 100. <i>β</i>2 refers to DQB1*02; <i>α</i>5 refers to DQA1*05; “x” denotes corresponding allele not determined; individuals with only one copy of the DQB1*02 allele were classified as <i>β</i>2/x (heterozygosis); individuals with two copies of the DQB1*02 allele were classified as <i>β</i>2/<i>β</i>2 (homozygosis);<i> trans</i> and<i> cis</i> indicate, respectively, <i>α</i>5 and <i>β</i>2 position in different or in the same chromosome 6 pair.</div>

Autoimmune Diseases

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Figure 1

Figure 1: Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease 