Table of Contents Author Guidelines Submit a Manuscript
Autoimmune Diseases
Volume 2016, Article ID 8252605, 11 pages
Research Article

Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus

1Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China
2College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China
3The Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, China
4Institute of Human Stem Cell Research at General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China

Received 17 January 2016; Accepted 15 February 2016

Academic Editor: Ricard Cervera

Copyright © 2016 Shuhong Chi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients. Methods. Sera from 134 patients with SLE and 84 healthy cohorts were tested for levels of sIL-7R and anti-C1q antibodies in terms of ELISA. Correlations of the sIL-7R and anti-C1q autoantibodies were evaluated. Results. The serum concentrations of sIL-7R and anti-C1q antibodies were significantly higher in SLE patients and LN patients in comparison with healthy individuals/controls and SLE patients with non-LN, respectively. In addition, both sIL-7R and anti-C1q concentrations were found to significantly correlate with the SLE disease activity as evaluated by SLEDAI scores. Interestingly, the serum sIL-7R concentration was strongly correlated with the level of anti-C1q antibodies (, ) but not statistically correlated with other serological markers, including the anti-dsDNA and complements C3 and C4 concentrations in SLE patients. Conclusion. Both serum sIL-7R and anti-C1q antibodies were strongly associated with disease activity and LN in SLE patients, suggesting that they may be reliable serological markers for identification of SLE patients with active diseases and LN.