Review Article

Neuronal Antibodies and Associated Syndromes

Table 2

Studies Investigating Autoantibodies Associated with Psychiatric Disorders.

CitationStudy Purpose DesignFindings

Jiwon and Levy, 2012 [43]To review the recent literature related to neuromyelitis optica.Systematic reviewThis study showed that neuromyelitis optica is a recurrent inflammatory disease that targets the spinal cord and optic nerves.

Marignier et al. 2010 [44]To study and discuss the prevalence, development, diagnosis, and management of Devic’s neuromyelitis optica (DNMO).Systematic reviewThis study showed that AQP4 antibodies are vital, specific biomarkers linked to the development of DNMO.

Höftberger, Rosenfeld, and Dalmau 2015 [45]To provide an update on paraneoplastic neurologic syndromes and examine their relationship with tumors and different types of immune responses.Meta-analysisParaneoplastic neurologic syndromes represent a diverse group of disorders caused by changes in the immune response. Early recognition of these conditions substantially assists in their treatment.

Honnorat et al. 2009 [46]To examine the association between paraneoplastic neurological disorders and anti-CV2/CRMP5 and anti-Hu antibodies.Longitudinal studyThis study reported numerous cases of uveo-retinal symptoms, chorea, cerebellar ataxia, and LEMS among patients positive for anti-CV2/CRMP5 antibodies.

Irani et al. 2010 [47]To examine the clinical spectrum of antibody-mediated CNS disorders while focusing on limbic encephalitis, Morvan syndrome and acquired NMT.Systematic reviewThis study linked LGI1 and CASPR2 to neurological conditions, such as limbic encephalitis, Morvan syndrome, and acquired NMT.