The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis

Figure 2

ROS effects on TCR signaling. TCR engagement leads to ROS production (red stars) from NOX2 at the plasma membrane. (a) Possible targets of ROS including LAT, ZAP70, SHP-1, Lck, and CD45. (b) Crosstalk of ROS with NF-κB signaling pathways. TCR, T-cell receptor; NOX2, NADPH oxidase 2; ROS, Reactive oxygen species; LAT, linker for activation of T cell; ZAP70, Zeta Chain Of T-Cell Receptor Associated Protein Kinase 70; SHP-1, Src homology 2 domain-containing protein tyrosine phosphatase 1; Lck, lymphocyte-specific protein tyrosine kinase; MEKK1, mitogen-activated protein kinase kinase kinase 1; NIK, NF-κB inducing kinase.

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