Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It?

Figure 2

Cytokine levels of patients being treated or not. RA patients who underwent leflunomide treatment (Lef + n = 7) exhibited lower serum IL-18 levels than patients who did not undergo any treatment (n = 60) ( = 0.0079) as well as those who were treated with prednisone (Pred + n = 10) ( = 0.0415). There was no statistical difference with the CG (Mann–Whitney test). MTX+ = methotrexate treatment n = 12.