Will 14-3-3η Be a New Diagnostic and Prognostic Biomarker in Rheumatoid Arthritis? A Prospective Study of Its Utility in Early Diagnosis and Response to Treatment

Table 4

Agreement (sensitivity and specificity) for serum RF, ACCP, and 14-3-3η to predict early RA patients (vs. control).

	AUC		95% CI		Cutoff	Sensitivity	Specificity	PPV	NPV
			LL	UL
RF	0.750	<0.001	0.646	0.830	>7.93	61.7	88.3	84.0	69.7
ACCP	0.817	<0.001	0.732	0.913	>21.20	68.3	95.0	93.1	75.0
14-3-3η	0.917	<0.001	0.854	0.998	>0.234	86.7	96.7	96.3	87.9

AUC: area under a curve, value: probability value, CI: confidence interval, NPV: negative predictive value, PPV: positive predictive value, : statistically significant at