T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

Table 3

Diagnostic criteria of IgG4⁺ mikulicz’s disease (approved by the Japanese Society for Sjögren’s Syndrome 2008) [131].

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Symmetrical swelling of at least two pairs of lachrymal, parotid, or submandibular glands for at least 3 months

AND Elevated serum IgG4 (>135 mg/dL)

OR Histopathological features including lymphocyte and IgG4+plasma cell infiltration (IgG4⁺ plasma cells/IgG⁺ plasma cells > 50%) with typical tissue fibrosis or sclerosis.

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