Characteristics of CD8⁺ and CD4⁺ Tissue-Resident Memory Lymphocytes in the Gastrointestinal Tract

Figure 1

Classification and features of GI-TRMs. Stimulated by antigens, T cells are primed in the draining lymph nodes by professional antigen-presenting dendritic cells (DCs). Followed by GI recruitment and pathogen clearance, partial of them differentiates into memory subsets and resident in local for a long time. Meanwhile, some subsets of TRMs exist at birth. The TRMs providing immediate and potent immune response to the recurrent antigens or infection. GI-TRMs developed unique phenotypic and functional characteristics reshaped by the local microenvironment such as surface marker and transcriptional regulation factors.