Review Article

Characteristics of CD8+ and CD4+ Tissue-Resident Memory Lymphocytes in the Gastrointestinal Tract

Table 1

The subsets of memory T cells.

SubsetPhenotypeLocationCirculationCytokine secretion

TCM (central memory T cell)CD44+, CD62L+, CD27+, CD28+, CD127+, CD69+/-, CD103-, CD11a+/-, KLRG1-, CX3CR1-, CCR7+, perforin-, and granzyme B-Lymph nodes, spleen, blood, and bone marrowHighPoor
TEM (effector memory T cell)CD44+, CD62L-, CD127+/-, CD69-, CD103-, CD11a+/-, KLRG1+, CX3CR1+, CCR7-, perforin+, granzyme B+, CCR8&10+(skin), and CCR9+ (GI)Spleen, lymph nodes, blood, GI, lung, heart, liver, skin, reproductive tract, and adipose tissueHighPrompt
TRM (tissue-resident memory T cell)CD44+, CD62L-, CD127+/-, CD69+/-, CD103+/-, CD11a+, KLRG1-, CX3CR1+/-, CCR7-, perforin+/-, granzyme B+/-, CCR8+(skin), CCR9+ & LAMP+ (GI), and CCR6+ (lung)Liver, lung, GI, skin, reproductive tract, and brainLowPrompt