The Challenge of Applications of Probiotics in Gastrointestinal Diseases

Table 2

Effect of bacteriocins on gastrointestinal health.

Bacteriocin	Class	Producing strain	Effect	References
Abp118	II	L. salivarius UCC118	Alleviate metabolic abnormalities associated with obesity	[39]
Pediocin PA-1	II	P. acidilactici PAC1.0	Reduce the intestinal colonization of VRE; inhibit the growth of DLD-1 and HT29	[38, 49, 96]
Garvicin ML	II	L. garvieae DCC43	Significantly increase the counts of total LAB and decrease the blood serum levels of triglycerides	[23]
Nisin	I	L. lactis	Regulate the intestinal immune; inhibit colorectal cancer in vitro	[43, 97, 98]
CBP22	I	Clostridium butyricum ZJU-F1	Prevention of LPS-induced gut barrier dysfunction by modulating the immune system	[42]
Plantaricin P1053	I	L. plantarum PBS067	Reduce proliferation of cancer-causing human intestinal cells	[47]
Reuterin	II	L. reuteri	Anticancer activity against HCT-116, SW480, RKO, and DLD-1 colorectal cancer cells	[45, 50]
Nisin A	I	L. lactis	Inhibit colorectal cancer cells LS180, SW48, HT29, and Caco-2	[99]
Pediocin K2a2-3	II	P. acidilactici K2a2-3	Inhibit the proliferation of HT29	[100, 101]
Bactofencin A	II	L. salivarius DPC6502	Alter the proportions of several important gut bacteria, such as Fusobacterium, Bacteroides, and Bifidobacterium	[102]
Plantaricin EF	II	L. plantarum 163	Ameliorate the effects of obesogenic diets; acute inflammatory bowel disease	[31, 44]
Gassericin A	V	L. gasseri LA39	Affect the differentiation and development of adipocytes	[103]