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Advances in Hematology
Volume 2009 (2009), Article ID 173439, 3 pages
http://dx.doi.org/10.1155/2009/173439
Case Report

Expansion of T Cells in an Immunocompetent Patient with Acute Toxoplasmosis

1Department of Hematology, Hospital San Pedro, Logroño, La Rioja 26006, Spain
2Department of Hematology, University Clinic, University of Navarra, 31008 Navarra, Spain
3Department of Microbiology, University Clinic, University of Navarra, 31008 Navarra, Spain
4Department of Immunology, University Clinic, University of Navarra, 31008 Navarra, Spain
5Department of Preventive Medicine and Public Health, University of Navarra, 31008 Navarra, Spain

Received 12 October 2008; Revised 12 May 2009; Accepted 16 June 2009

Academic Editor: Luigi Daniele Notarangelo

Copyright © 2009 R. García-Muñoz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CD57 T cells increase in several viral infections like cytomegalovirus, herpesvirus, parvovirus, HIV and hepatitis C virus and are associated with several clinical conditions related to immune dysfunction and ageing. We report for the first time an expansion of CD8 CD57 T cells in a young patient with an acute infection with Toxoplasma gondii. Our report supports the concept that CD8 CD57 T cells could be important in the control of chronic phase of intracellular microorganisms and that the high numbers of these cells may reflect the continuing survey of the immune system, searching for parasite proliferation in the tissues.